Fixing Tissue for Optimal Results: Part 1 The first step in the histological process is the isolation and fixation of the desired tissue. Fixation is a chemical process by which biological tissues are preserved from decay, preventing autolysis or putrefaction. The purpose of fixation is to preserve tissues permanently in as life-like a state as […]
Conducting an IHC Study – Factors to Consider: Part II Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
Conducting an IHC Study – Factors to Consider: Part 1 Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
The Histological Analysis of Implantable Medical Devices Resin/Plastic Sectioning vs Cutting and GrindingResin/plastic histology is typically used to examine hard tissue such as bone and implanted medical device interaction with surrounding tissues. There are two basic methodologies: grinding, also called cutting and grinding, and sectioning, which is done on a rotary microtome. In either method, […]
Wax-it Histology Services Receives GLP Accreditation VANCOUVER, BC (October 16, 2012) — Wax-it Histology Services, a Canadian-based preclinical histopathology contract research organization (CRO), is pleased to announce that its facility is now GLP accredited by the Standards Council of Canada (SCC), Canadian GLP Monitoring Authority. GLP accreditation of Wax-it Histology Services – based upon audit of […]
Conducting Biocompatibility Testing for a Medical Device: Part II Interview with Jeff Geesin, Research Director & Medical Device Consultant About Jeff GeesinJeff Geesin is a biochemist with extensive experience in corporate research and technical expertise in extracellular matrix biology, wound repair and regeneration, tissue engineering/regenerative medicine, and preclinical models of disease for testing therapeutic approaches. […]
Challenges Faced by Medical Device Companies: Part II Interview with Ian McDougall, CEO of Evasc Medical SystemsAbout Ian McDougall, BASc President & CEO of Evasc Medical Systems Ian has an engineering degree from the University of British Columbia and has been working in the medical device sector for over 14 years. He has co-founded several […]
Biocompatibility of Implants/Medical Devices Histological evaluation is the preferred method to examine the in situ interaction between the implanted device and surrounding tissues. With paraffin histology, it is difficult to maintain the device/tissue interaction when examining the interface between two materials. This difficulty arises as a result of the differences in density and material properties […]
Wax-it Histology Services Successfully Completes 2 GLP Studies VANCOUVER, BC (September 8, 2011) — Wax-it Histology Services, a Canadian based preclinical histopathology contract research organization (CRO), is pleased to announce the successful completion of 2 studies under Good Laboratory Practices (GLP) requirements. GLP audits of the site and the studies were conducted by an independent QA […]
