Table of Contents 1. Introduction Western Immunoblot in canada has emerged as a critical technique in the realm of molecular diagnostics and biomedical research. This method, which allows for the detection of specific proteins in complex mixtures, has become indispensable for clinical laboratories, academic research centers, and biotech companies across Canada. In this article, we […]
Table of Contents 1. Introduction Imaging and Analysis in canada play a critical role in modern healthcare, research, and technological innovation. In today’s rapidly advancing medical landscape, the integration of state-of-the-art imaging technologies with sophisticated analytical tools is transforming how clinicians diagnose, monitor, and treat patients. This comprehensive article explores the evolution, current methodologies, and […]
Table of Contents 1. Introduction Pathology Services in canada are at the heart of modern healthcare, providing the essential diagnostic backbone for disease detection and patient management. In this article, we explore the expansive world of Pathology Services in canada, discussing its evolution, current technologies, and its pivotal role in both clinical and research settings. […]
Table of Contents 1. Introduction Immunohistochemistry IHC in Canada is a transformative field that merges immunology with histopathology to detect specific proteins in tissue samples. In this article, we delve deep into the world of Immunohistochemistry IHC in Canada to explore its evolution, advanced techniques, and practical applications in diagnostics and research. Therefore, whether you […]
Table of Contents 1. Introduction Immunohistochemistry in Canada is a rapidly evolving field that plays a crucial role in both clinical diagnostics and research. In this article, we delve into the advancements, techniques, and applications of immunohistochemistry across Canada. Therefore, readers seeking to understand the intricacies of this discipline will find comprehensive insights and actionable […]
Table of Contents Introduction to Paraffin Embedding Paraffin embedding is one of the most widely used techniques in histopathology. This method is employed to preserve tissue samples for microscopic examination and study. The process involves embedding biological tissue specimens in molten paraffin wax, which hardens to create a stable structure that can be thinly sectioned […]
Introduction Preclinical Histopathology plays a pivotal role in the field of drug development, offering critical insights into the safety and efficacy of new pharmaceutical compounds. It involves the detailed examination of tissue samples to detect any signs of adverse effects caused by experimental drugs, allowing researchers and pharmaceutical companies to make informed decisions before moving […]
Histopathological Considerations for IHC-based Studies In any biological experiment, the quality of the data generated is directly related to the quality of the samples and methods used in the study. Ideally, animal studies are designed to include a single variable between the experimental groups. It is essential to have appropriate control groups against which data […]
Advantages and Drawbacks of Paraffin and Frozen Tissues Formalin-fixed paraffin embedded (FFPE) and frozen tissues are widely used histology methods for assessing tissue samples. Depending on the downstream applications of the study, one histology method may have better advantages to the other. This article will cover both advantages and drawbacks of both histology methods to […]
Fixation and Shipment of Wet Tissues for Paraffin Embedding Downstream Services Experimental tissue samples are important to any study, so before you sacrifice your animal or start preparing buffers, here a few fundamental techniques and considerations that will help optimize your results before sending those samples to us for further histopathological analysis. Choosing Your […]
Fixation and Shipment of Tissue Samples for Frozen Downstream Applications The idea of fixing and shipping samples for frozen sectioning can seem like an intimidating task. In reality, it’s much more straightforward than preparing tissue for paraffin applications. Before you start collecting your tissue samples, here are some tips and considerations to optimize your results […]
Why More Organizations are Outsourcing Histopathology Histopathology plays a large role in medical and pharmaceutical research. However, when performing histopathology in-house it can be expensive, time consuming, or in some cases a non-core function. Let’s discuss the topic by analyzing reasons why organizations are outsourcing histopathology services. Improves your bottom line and management of resources […]
Histopathology for Oncology Therapeutics When developing a cancer therapeutic, understanding how proteins along the targeted metabolic pathway are modulated is essential in understanding the molecule’s mechanism of action. Immunohistochemistry (IHC) is essential in determining protein expression and localization in tissues of interest. IHC is critical in determining protein biomarker detection, localization, and semi-quantitative expression levels. […]
Resin Histology by Device Type (Cut & Grind vs. Microtomy) Resin/plastic histology is typically used to examine hard tissue, such as bone, and to study how implanted medical devices interact with surrounding tissues. There are two basic methods for resin histology: grinding, also called cutting and grinding (or ‘saw and grind’) using a precision diamond […]
Fixing Tissue for Optimal Results: Part II The first step in the histological process is the isolation and fixation of the desired tissue. Fixation is a chemical process by which biological tissues are preserved from decay, preventing autolysis or putrefaction. The purpose of fixation is to preserve tissues permanently, in as life-like a state as […]
Fixing Tissue for Optimal Results: Part 1 The first step in the histological process is the isolation and fixation of the desired tissue. Fixation is a chemical process by which biological tissues are preserved from decay, preventing autolysis or putrefaction. The purpose of fixation is to preserve tissues permanently in as life-like a state as […]
Conducting an IHC Study – Factors to Consider: Part II Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
Conducting an IHC Study – Factors to Consider: Part 1 Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
The Histological Analysis of Implantable Medical Devices Resin/Plastic Sectioning vs Cutting and GrindingResin/plastic histology is typically used to examine hard tissue such as bone and implanted medical device interaction with surrounding tissues. There are two basic methodologies: grinding, also called cutting and grinding, and sectioning, which is done on a rotary microtome. In either method, […]
Conducting Biocompatibility Testing for a Medical Device: Part II Interview with Jeff Geesin, Research Director & Medical Device Consultant About Jeff GeesinJeff Geesin is a biochemist with extensive experience in corporate research and technical expertise in extracellular matrix biology, wound repair and regeneration, tissue engineering/regenerative medicine, and preclinical models of disease for testing therapeutic approaches. […]
Challenges Faced by Medical Device Companies: Part II Interview with Ian McDougall, CEO of Evasc Medical SystemsAbout Ian McDougall, BASc President & CEO of Evasc Medical Systems Ian has an engineering degree from the University of British Columbia and has been working in the medical device sector for over 14 years. He has co-founded several […]
Biocompatibility of Implants/Medical Devices Histological evaluation is the preferred method to examine the in situ interaction between the implanted device and surrounding tissues. With paraffin histology, it is difficult to maintain the device/tissue interaction when examining the interface between two materials. This difficulty arises as a result of the differences in density and material properties […]
