Fixation and Shipment of Tissue Samples for Frozen Downstream Applications The idea of fixing and shipping samples for frozen sectioning can seem like an intimidating task. In reality, it’s much more straightforward than preparing tissue for paraffin applications. Before you start collecting your tissue samples, here are some tips and considerations to optimize your results […]
Why More Organizations are Outsourcing Histopathology Histopathology plays a large role in medical and pharmaceutical research. However, when performing histopathology in-house it can be expensive, time consuming, or in some cases a non-core function. Let’s discuss the topic by analyzing reasons why organizations are outsourcing histopathology services. Improves your bottom line and management of resources […]
Histopathology for Oncology Therapeutics When developing a cancer therapeutic, understanding how proteins along the targeted metabolic pathway are modulated is essential in understanding the molecule’s mechanism of action. Immunohistochemistry (IHC) is essential in determining protein expression and localization in tissues of interest. IHC is critical in determining protein biomarker detection, localization, and semi-quantitative expression levels. […]
Resin Histology by Device Type (Cut & Grind vs. Microtomy) Resin/plastic histology is typically used to examine hard tissue, such as bone, and to study how implanted medical devices interact with surrounding tissues. There are two basic methods for resin histology: grinding, also called cutting and grinding (or ‘saw and grind’) using a precision diamond […]
Fixing Tissue for Optimal Results: Part II The first step in the histological process is the isolation and fixation of the desired tissue. Fixation is a chemical process by which biological tissues are preserved from decay, preventing autolysis or putrefaction. The purpose of fixation is to preserve tissues permanently, in as life-like a state as […]
Fixing Tissue for Optimal Results: Part 1 The first step in the histological process is the isolation and fixation of the desired tissue. Fixation is a chemical process by which biological tissues are preserved from decay, preventing autolysis or putrefaction. The purpose of fixation is to preserve tissues permanently in as life-like a state as […]
Conducting an IHC Study – Factors to Consider: Part II Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
Conducting an IHC Study – Factors to Consider: Part 1 Immunohistochemistry (IHC) is a method for demonstrating the presence and location of proteins in tissue. IHC enables the observation of processes in the context of intact tissue, which is especially useful for assessing the progression and treatment of certain diseases. Immunohistochemical staining is accomplished with […]
The Histological Analysis of Implantable Medical Devices Resin/Plastic Sectioning vs Cutting and GrindingResin/plastic histology is typically used to examine hard tissue such as bone and implanted medical device interaction with surrounding tissues. There are two basic methodologies: grinding, also called cutting and grinding, and sectioning, which is done on a rotary microtome. In either method, […]
Conducting Biocompatibility Testing for a Medical Device: Part II Interview with Jeff Geesin, Research Director & Medical Device Consultant About Jeff GeesinJeff Geesin is a biochemist with extensive experience in corporate research and technical expertise in extracellular matrix biology, wound repair and regeneration, tissue engineering/regenerative medicine, and preclinical models of disease for testing therapeutic approaches. […]
